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Epidermal Growth Factor Receptor (EGFR) Antibody
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Catalogue No: abx025533
Price:
US$326.25
(Size: 80 µl)
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The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
Research Articles on Epidermal Growth Factor Receptor (EGFR)
| Target | Epidermal Growth Factor Receptor (EGFR) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Mouse |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 1163-1191 amino acids from the C-terminal region of human EGFR. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P00533 (UniProt, ExPASy) |
| UniProt Entry Name | EGFR_HUMAN |
| NCBI Accession | NP_005219.2 NP_958439.1 NP_958440.1 NP_958441.1 |
| KEGG | hsa:1956 |
| String | 9606.ENSP00000275493 |
| Molecular Weight | Calculated MW: 134 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |