Epidermal Growth Factor Receptor (EGFR) Antibody

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

Target	Epidermal Growth Factor Receptor (EGFR)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Mouse
Recommended dilutions	WB: 1/2000, IHC-P: 1/25, FCM: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified His-tagged Human EGFR protein (Fragment)
Isotype	IgG1 Kappa
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P00533 (UniProt, ExPASy)
UniProt Entry Name	EGFR_HUMAN
NCBI Accession	NP_005219.2 NP_958439.1 NP_958440.1 NP_958441.1
KEGG	hsa:1956
String	9606.ENSP00000275493
Molecular Weight	Calculated MW: 134 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Epidermal Growth Factor Receptor (EGFR)

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