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Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) Antibody
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Catalogue No: abx027889
Price:
US$326.25
(Size: 80 µl)
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EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism (By similarity).
Research Articles on Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3)
| Target | Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 203-231 amino acids from the C-terminal region of human EGLN3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9H6Z9 (UniProt, ExPASy) |
| UniProt Secondary AC | Q2TA79, Q3B8N4, Q6P1R2 |
| UniProt Entry Name | EGLN3_HUMAN |
| Gene Symbol | EGLN3 |
| String | 9606.ENSP00000250457 |
| Molecular Weight | Calculated MW: 27.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Rat EGLN3. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |