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EIF2S1 (pS49) Antibody
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Catalogue No: abx000389
Price:
US$551.00
(Size: 100 µl)
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EIF2S1 (pS49) Antibody is a Rabbit Polyclonal antibody against EIF2S1 (pS49). The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987).
Research Articles on EIF2S1 (pS49)
| Target | EIF2S1 (pS49) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A phospho specific peptide corresponding to residues surrounding S49 of human EIF2S1 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P05198 (UniProt, ExPASy) |
| UniProt Entry Name | IF2A_HUMAN |
| Gene Symbol | EIF2S1 |
| GeneID | 1965 |
| KEGG | hsa:1965 |
| String | 9606.ENSP00000256383 |
| Molecular Weight | Calculated MW: 36 kDa Observed MW: 40 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |