Eukaryotic Translation Initiation Factor 3 Subunit C (EIF3C) Antibody

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

Target	Eukaryotic Translation Initiation Factor 3 Subunit C (EIF3C)
Clonality	Polyclonal
Reactivity	Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 538-566 amino acids from the Central region of human EIF3C.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q99613 (UniProt, ExPASy)
UniProt Secondary AC	A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q9BW98
UniProt Entry Name	EIF3C_HUMAN
Gene Symbol	EIF3C
KEGG	hsa:8663
String	9606.ENSP00000332604
Molecular Weight	Calculated MW: 105 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Human, Rat, Cow and Xenopus EIF3C.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Eukaryotic Translation Initiation Factor 3 Subunit C (EIF3C)

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