+44 (0) 1223 755950
+1 832 327 7413
Eukaryotic Translation Initiation Factor 3 Subunit E (EIF3E) Antibody
REQUEST MORE INFO
Catalogue No: abx030996
Price:
US$326.25
(Size: 80 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD) ; may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
Research Articles on Eukaryotic Translation Initiation Factor 3 Subunit E (EIF3E)
| Target | Eukaryotic Translation Initiation Factor 3 Subunit E (EIF3E) |
| Clonality | Polyclonal |
| Reactivity | Human, Zebrafish |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 248-276 amino acids from the Central region of human EIF3E. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P60228 (UniProt, ExPASy) |
| UniProt Secondary AC | O43902, Q64058, Q64059, Q64252, Q6FG33, Q8WVK4 |
| UniProt Entry Name | EIF3E_HUMAN |
| NCBI Accession | NP_001559.1 |
| KEGG | hsa:3646 |
| String | 9606.ENSP00000220849 |
| Molecular Weight | Calculated MW: 52.2 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat, Cow, Monkey and Xenopus EIF3E. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |