Eukaryotic Initiation Factor 4A-II (EIF4A2) Antibody

Eukaryotic initiation factor 4A plays an important role in the binding of mRNA to the 43S preinitiation complex when protein synthesis begins. Two highly homologous forms of functional EIF4A genes, Eif4a1 and Eif4a2, have been isolated in mice; yeast cells also possess 2 EIF4A genes, TIF1 and TIF2. The murine Eif4a and yeast TIF genes appear to belong to a DEAD-box gene family, whose members exhibit extensive amino acid similarity and contain the asp-glu-ala-asp (DEAD) sequence. DEAD-box genes have been identified in species ranging from E-coli to humans. Their function appears to be related to transcriptional/translational regulation (referenced from OMIM).

Target	Eukaryotic Initiation Factor 4A-II (EIF4A2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/4000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 333-360 amino acids from the C-terminal region of human EIF4A2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q14240 (UniProt, ExPASy)
UniProt Secondary AC	D3DNU9, Q53XJ6, Q96B90, Q96EA8
UniProt Entry Name	IF4A2_HUMAN
KEGG	hsa:1974
String	9606.ENSP00000326381
Molecular Weight	Calculated MW: 46.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat, Cow and Monkey EIF4A2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Eukaryotic Initiation Factor 4A-II (EIF4A2)

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