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Eukaryotic Translation Initiation Factor 4E (EIF4E) Antibody
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Catalogue No: abx010704
Price:
US$420.50
(Size: 100 µl)
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eIF4E, a protein modulates translation of maternal mRNAs in early embryos before the onset of zygotic transcription. eIF4E also influences the overall rate of translation. eIF4E binds to the 7 methyl GTP cap structure of eukaryotic mRNAs. Phosphorylation of eIF4E on serine 209 regulates the affinity of this protein for the 7 methyl GTP cap and/or RNA. Phosphorylation also enhances the interaction of eIF4E with eIF4G, which form a complex known as eIF4F. eIF4E phosphorylation is correlated with increased translational rate in a number of cell types. Several kinases are currently being investigated as potential regulators of eIF4E including PKC and/or the MAP kinase activated Mnk.
Research Articles on Eukaryotic Translation Initiation Factor 4E (EIF4E)
| Target | Eukaryotic Translation Initiation Factor 4E (EIF4E) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human EIF4E expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P06730 (UniProt, ExPASy) |
| UniProt Secondary AC | B7Z6V1, D6RCQ6, Q96E95 |
| UniProt Entry Name | IF4E_HUMAN |
| Gene Symbol | EIF4E |
| GeneID | 1977 |
| OMIM | 133440 |
| HGNC | 3287 |
| KEGG | hsa:1977 |
| Ensembl | ENSG00000151247 |
| Molecular Weight | 25 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |