Eukaryotic Translation Initiation Factor 4 Gamma 2 (EIF4G2) Antibody

EIF4G2 Antibody is a Rabbit Polyclonal antibody against EIF4G2. Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.

Target	Eukaryotic Translation Initiation Factor 4 Gamma 2 (EIF4G2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200, IP: 0.5-4 µg/200-400 µg whole cell extracts. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 320-490 of human EIF4G2/p97.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P78344 (UniProt, ExPASy)
UniProt Entry Name	IF4G2_HUMAN
Gene Symbol	EIF4G2
GeneID	1982
NCBI Accession	NP_001409.3
KEGG	hsa:1982
String	9606.ENSP00000433664
Molecular Weight	Calculated MW: 102 kDa Observed MW: 100 kDa
Buffer	PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Eukaryotic Translation Initiation Factor 4 Gamma 2 (EIF4G2)

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