ELK1, Member Of ETS Oncogene Family (ELK1) Antibody

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Catalogue No: abx015738
Price: US$427.75
(Size: 100 µl)

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Datasheet SDS
The transcription factor ELK1 is a family of member of ETS oncogene family and of the ternary complex factor (TCF) subfamily,which is located on chromosome Xp11.2 and stimulates transcription.binds to purine-rich DNA sequences.Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene.The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade.Elk1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C terminus,It appears to be a direct target of activated MAP kinase.Biochemical studies indicate that Elk1 is a good substrate for MAP kinase, the kinetics of Elk1phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block Elk1 activation in vivo.More recent studies have shown that Elk1 is also a target of the Stress Activated Kinase SAPK/JNK.Phosphorylation of Elk1 has also been implicated in synaptic plasticity in the adult hippocampus.

Target ELK1, Member Of ETS Oncogene Family (ELK1)
Clonality Monoclonal
Reactivity Human
Tested Applications ELISA
Host Mouse
Recommended dilutions ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Purified recombinant fragment of ELK1 expressed in E. coli.
Isotype IgG1
Form Liquid
Purification Unpurified ascites.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P19419 (UniProt, ExPASy)
UniProt Secondary AC B2R7H4, O75606, O95058, Q969X8, Q9UJM4
Gene Symbol ELK1
GeneID 2002
OMIM 311040
HGNC 3321
Ensembl ENSG00000126767
Buffer Ascitic fluid containing 0.03% sodium azide.
Concentration Not determined.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on ELK1, Member Of ETS Oncogene Family (ELK1)


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