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Epithelial Discoidin Domain-Containing Receptor 1 (DDR1) Antibody
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Catalogue No: abx146917
Price:
US$406.00
(Size: 100 µg)
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Epithelial Discoidin Domain-Containing Receptor 1 (DDR1) Antibody is a Rabbit Polyclonal antibody for the detection of DDR1. Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
Research Articles on Epithelial Discoidin Domain-Containing Receptor 1 (DDR1)
| Target | Epithelial Discoidin Domain-Containing Receptor 1 (DDR1) |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | discoidin domain receptor tyrosine kinase 1 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | Q08345 (UniProt, ExPASy) |
| Gene Symbol | DDR1 |
| GeneID | 780 |
| OMIM | 600408 |
| HGNC | 2730 |
| Ensembl | ENSG00000137332 |
| Molecular Weight | Observed MW: 101 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |