V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ERBB3) Antibody

ErbB3, a member of the EGF receptor family, binds and is activated by neuregulins and NTAK. It potentially forms a heterodimer with each of the other ERBB receptors. This protein is predominantly expressed in epithelial tissues and brain. The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins. Ligand-binding may increase phosphorylation on tyrosine residues and promote its association with the p85 subunit of phosphatidylinositol 3-kinase ErbB3 is overexpressed in a subset of human mammary tumors.

Target	V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ERBB3)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 24-55 amino acids from the N-terminal region of human ERBB3.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P21860 (UniProt, ExPASy)
UniProt Secondary AC	A8K6L6, B4DIK7, B4DV32, E9PDT8, Q9BUD7
UniProt Entry Name	ERBB3_HUMAN
NCBI Accession	NP_001005915.1 NP_001973.2
KEGG	hsa:2065
String	9606.ENSP00000267101
Molecular Weight	Calculated MW: 148 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ERBB3)

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