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V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ERBB3) Antibody
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Catalogue No: abx033547
Price:
US$290.00
(Size: 80 µl)
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ErbB3, a member of the EGF receptor family, binds and is activated by neuregulins and NTAK. It potentially forms a heterodimer with each of the other ERBB receptors. This protein is predominantly expressed in epithelial tissues and brain. The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins. Ligand-binding may increase phosphorylation on tyrosine residues and promote its association with the p85 subunit of phosphatidylinositol 3-kinase ErbB3 is overexpressed in a subset of human mammary tumors.
Research Articles on V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ERBB3)
| Target | V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ERBB3) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 24-55 amino acids from the N-terminal region of human ERBB3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P21860 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K6L6, B4DIK7, B4DV32, E9PDT8, Q9BUD7 |
| UniProt Entry Name | ERBB3_HUMAN |
| NCBI Accession | NP_001005915.1 NP_001973.2 |
| KEGG | hsa:2065 |
| String | 9606.ENSP00000267101 |
| Molecular Weight | Calculated MW: 148 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |