+44 (0) 1223 755950
+1 832 327 7413
V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ERBB3) Antibody
REQUEST MORE INFO
Catalogue No: abx000910
Price:
US$232.00
(Size: 20 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
ERBB3 Antibody is a Rabbit Polyclonal antibody against ERBB3. This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
Research Articles on V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ERBB3)
| Target | V-Erb B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ERBB3) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1275-1342 of human ErbB3/HER3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P21860 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K6L6, B4DIK7, B4DV32, E9PDT8, Q9BUD7 |
| UniProt Entry Name | ERBB3_HUMAN |
| Gene Symbol | ERBB3 |
| GeneID | 2065 |
| NCBI Accession | NP_001973.2 |
| KEGG | hsa:2065 |
| String | 9606.ENSP00000267101 |
| Molecular Weight | Calculated MW: 148 kDa Observed MW: 185 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |