DNA Excision Repair Protein ERCC-1 (ERCC1) Antibody

ERCC1 Antibody is a Rabbit Polyclonal antibody against ERCC1. The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.

Target	DNA Excision Repair Protein ERCC-1 (ERCC1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human ERCC1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P07992 (UniProt, ExPASy)
UniProt Secondary AC	B2RC01, B3KRR0, Q7Z7F5, Q96S40
UniProt Entry Name	ERCC1_HUMAN
Gene Symbol	ERCC1
GeneID	2067
NCBI Accession	NP_973730.1
KEGG	hsa:2067
String	9606.ENSP00000013807
Molecular Weight	Calculated MW: 33 kDa Observed MW: 39 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on DNA Excision Repair Protein ERCC-1 (ERCC1)

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