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ETS Translocation Variant 4 (ETV4) Antibody
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Catalogue No: abx010756
Price:
US$420.50
(Size: 100 µl)
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ETV4: ets variant gene 4 (E1A enhancer binding protein, E1AF), also known as PEA3. Several members of the Ets gene family are known to encode sequencespecific DNA binding proteins. These include mouse PU.1, mouse and human Ets-1, Drosophila E74, chicken and human Ets-2 and rat GABP alpha. Each of these proteins recognizes similar motifs in DNA that share a centrally located 5'-GGAA-3' element. For instance, PEA3 binds the motif 5'-AGGAAG-3' (the PEA-3 motif), but does not bind to the sequence 5'-AGGAAC-3', recognized by PU.1, although PU.1 binds equally well to both sequences. It appears that all of the Ets proteins recognize the same central core sequence but that each protein interacts with unique sequences that flank this core. PEA3 is expressed at readily detectable levels in cells of epithelial and fibroblastic origin but is not expressed in hematopoietic cells. This is in contrast to other members of the Ets gene family, such as Ets-1, Ets-2 and Fli-1, each of which is expressed primarily in cells of hematopoietic origin.
Research Articles on ETS Translocation Variant 4 (ETV4)
| Target | ETS Translocation Variant 4 (ETV4) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human ETV4 (aa50-109) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P43268 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K314, B7Z5J3, B7Z9J6, Q96AW9 |
| UniProt Entry Name | ETV4_HUMAN |
| Gene Symbol | ETV4 |
| GeneID | 2118 |
| OMIM | 600711 |
| HGNC | 3493 |
| KEGG | hsa:2118 |
| Ensembl | ENSG00000175832 |
| String | 9606.ENSP00000321835 |
| Molecular Weight | 54 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |