Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 (4EBP1) Antibody

Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 (4EBP1) Antibody is a Rabbit Polyclonal antibody for the detection of 4EBP1.

Eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) is a member of 4EBPs family, which regulate the translation of a subset of mRNA by competing with eIF4G for binding to eIF4E, thus preventing the assembly of the eIF4F complex. The eIF4F facilitates the recruitment of other translation initiation factors to form the complex and then initiates cap-dependent translation.4EBP1 also mediates the regulation of protein translation by growth factors, hormones and other stimuli that signal through the MAP kinase and mTORC1 pathways. There are three forms of 4EBP1, alpha, beta and gamma.

Target	Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 (4EBP1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	eukaryotic translation initiation factor 4E binding protein 1
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	Q13541 (UniProt, ExPASy)
UniProt Secondary AC	B2R502, D3DSW8, Q6IBN3
UniProt Entry Name	4EBP1_HUMAN
Gene Symbol	EIF4EBP1
GeneID	1978
OMIM	602223
HGNC	3288
KEGG	hsa:1978
Ensembl	ENSG00000187840
String	9606.ENSP00000340691
Molecular Weight	Observed MW: 17 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 (4EBP1)

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