General Transcription And DNA Repair Factor IIH Helicase Subunit XPD (ERCC2) Antibody

General Transcription And DNA Repair Factor IIH Helicase Subunit XPD (ERCC2) Antibody is a Rabbit Polyclonal antibody for the detection of ERCC2.

ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.

Target	General Transcription And DNA Repair Factor IIH Helicase Subunit XPD (ERCC2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	excision repair cross-complementing rodent repair deficiency, complementation group 2
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P18074 (UniProt, ExPASy)
UniProt Secondary AC	Q2TB78, Q2YDY2, Q7KZU6, Q8N721
UniProt Entry Name	ERCC2_HUMAN
Gene Symbol	ERCC2
GeneID	2068
OMIM	126340
HGNC	3434
KEGG	hsa:2068
Ensembl	ENSG00000104884
String	9606.ENSP00000375809
Molecular Weight	Observed MW: 80 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on General Transcription And DNA Repair Factor IIH Helicase Subunit XPD (ERCC2)

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