Enhancer Of Zeste Homolog 1 (EZH1) Antibody

EZH1 encodes a protein of 747 amino acids that displays 55% amino acid identity overall with the Drosophila homolog.1 The strong sequence conservation suggested potential roles for EZH1 in human development as a transcriptional regulator and as a component of protein complexes that preserve heterochromatin stability. EZH1 is expressed as 2 major transcripts in all adult and fetal human tissues evaluated. Analysis of an EZH1 cDNA revealed an unusual splicing event involving EZH1 and a tandemly linked gene GPR2 and suggested a potential mechanism for modifying the EZH1 protein in the conserved C-terminal domain. The GPR2 gene maps to 17q21.1-q21.3 in the vicinity of the BRCA1 gene.

Target	Enhancer Of Zeste Homolog 1 (EZH1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 393-422 amino acids from the Central region of human EZH1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q92800 (UniProt, ExPASy)
UniProt Entry Name	EZH1_HUMAN
KEGG	hsa:2145
String	9606.ENSP00000404658
Molecular Weight	Calculated MW: 85.3 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow EZH1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Enhancer Of Zeste Homolog 1 (EZH1)

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