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Long-Chain-Fatty-Acid-CoA Ligase 6 (FACL6) Antibody
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Catalogue No: abx031625
Price:
US$326.25
(Size: 80 µl)
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FACL6 is involved in activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. It plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. FACL6 is expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derieved from fetal liver, haemopoietic stem cells from cord blood, bone marrow, and brain. Expression is low at earlier stages of erythroid development but is very high in reticulocytes. This protein is involved in myelodysplastic syndrome (MDS) with basophilia, acute myelogenous leukemia (AML) with eosinophilia, and acute eosinophilic leukemia (AEL). It is characterized by a chromosomal translocation t (5;12) (q31;p13) that involves ETV6 and ACSL6.
Research Articles on Long-Chain-Fatty-Acid-CoA Ligase 6 (FACL6)
| Target | Long-Chain-Fatty-Acid-CoA Ligase 6 (FACL6) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 240-270 amino acids from the Central region of human FACL6. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9UKU0 (UniProt, ExPASy) |
| UniProt Secondary AC | J3KPG3, O94924, O95829, Q108M9, Q108N0, Q4G191, Q86TN7 |
| UniProt Entry Name | ACSL6_HUMAN |
| String | 9606.ENSP00000368566 |
| Molecular Weight | Calculated MW: 77.8 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |