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FAS-Associated Death Domain Protein (FADD) Antibody
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Catalogue No: abx031108
Price:
US$326.25
(Size: 80 µl)
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The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Research Articles on FAS-Associated Death Domain Protein (FADD)
| Target | FAS-Associated Death Domain Protein (FADD) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 106-135 amino acids from the Central region of human FADD. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q13158 (UniProt, ExPASy) |
| UniProt Secondary AC | Q14866, Q6IBR4 |
| UniProt Entry Name | FADD_HUMAN |
| KEGG | hsa:8772 |
| String | 9606.ENSP00000301838 |
| Molecular Weight | Calculated MW: 23.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |