FAS-Associated Death Domain Protein (FADD) Antibody

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Catalogue No: abx004459
Price: US$348.00
(Size: 60 µl)

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FAS-Associated Death Domain Protein (FADD) Antibody FAS-Associated Death Domain Protein (FADD) Antibody FAS-Associated Death Domain Protein (FADD) Antibody FAS-Associated Death Domain Protein (FADD) Antibody

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Datasheet SDS
FADD Antibody is a Rabbit Polyclonal antibody against FADD. The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Target FAS-Associated Death Domain Protein (FADD)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IF/ICC, IP
Host Rabbit
Recommended dilutions WB: 1/200 - 1/2000, IF/ICC: 1/50 - 1/200, IP: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein corresponding to mouse FADD
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q13158 (UniProt, ExPASy)
UniProt Secondary AC Q14866, Q6IBR4
UniProt Entry Name FADD_HUMAN
Gene Symbol FADD
GeneID 8772
NCBI Accession NP_003815.1
KEGG hsa:8772
String 9606.ENSP00000301838
Molecular Weight Observed MW: 28 kDa
Buffer PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol.
Concentration 1 mg/ml
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on FAS-Associated Death Domain Protein (FADD)


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