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FADD (pS191) Antibody
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Catalogue No: abx031860
Price:
US$326.25
(Size: 80 µl)
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FADD is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Research Articles on FADD (pS191)
| Target | FADD (pS191) |
| Clonality | Polyclonal |
| Target Modification | Ser191 |
| Modification | Phosphorylation |
| Reactivity | Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S191 of mouse FADD. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by protein G affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q61160 (UniProt, ExPASy) |
| UniProt Secondary AC | Q3TC37, Q61082 |
| UniProt Entry Name | FADD_MOUSE |
| KEGG | mmu:14082 |
| String | 10090.ENSMUSP00000033394 |
| Molecular Weight | Calculated MW: 23 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |