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Fanconi Anemia Complementation Group D2 (FANCD2) Antibody
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Catalogue No: abx001687
Price:
US$203.00
(Size: 20 µl)
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Fanconi Anemia Group D2 Protein (FANCD2) Antibody is a Rabbit Polyclonal antibody against Fanconi Anemia Group D2 Protein (FANCD2). The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), Fanconi Anemia Group D2 Protein (FANCD2), FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Research Articles on Fanconi Anemia Complementation Group D2 (FANCD2)
| Target | Fanconi Anemia Complementation Group D2 (FANCD2) |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | WB, IF/ICC, IP |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200, IP: 0.5-4 µg/200-400 µg whole cell extracts. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 540-720 of FANCD2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9BXW9 (UniProt, ExPASy) |
| UniProt Secondary AC | Q2LA86, Q69YP9, Q6PJN7, Q9BQ06, Q9H9T9 |
| UniProt Entry Name | FACD2_HUMAN |
| Gene Symbol | FANCD2 |
| GeneID | 2177 |
| NCBI Accession | NP_001018125.1 |
| String | 9606.ENSP00000287647 |
| Molecular Weight | Calculated MW: 164 kDa Observed MW: 180 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |