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TNF Receptor Superfamily Member 6 / CD95 / TNFRSF6 (FAS) Antibody
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Catalogue No: abx011831
Price:
US$420.50
(Size: 100 µl)
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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF- kappa B, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Research Articles on TNF Receptor Superfamily Member 6 / CD95 / TNFRSF6 (FAS)
| Target | TNF Receptor Superfamily Member 6 / CD95 / TNFRSF6 (FAS) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IF/ICC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human FAS expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified from ascites by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P25445 (UniProt, ExPASy) |
| UniProt Entry Name | TNR6_HUMAN |
| Gene Symbol | FAS |
| GeneID | 355 |
| OMIM | 134637 |
| HGNC | 11920 |
| KEGG | hsa:355 |
| Ensembl | ENSG00000026103 |
| String | 9606.ENSP00000347979 |
| Molecular Weight | 37.7 kDa |
| Buffer | PBS, containing 0.05% sodium azide. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |