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Fc Fragment of IgG Low Affinity IIIa Receptor (FCGR3A) Antibody
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Catalogue No: abx025413
Price:
US$623.50
(Size: 100 µl)
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This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This antibody is supplied as crude ascites.
Research Articles on Fc Fragment of IgG Low Affinity IIIa Receptor (FCGR3A)
| Target | Fc Fragment of IgG Low Affinity IIIa Receptor (FCGR3A) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Mouse |
| Recommended dilutions | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 60-88 amino acids from human FCGR3A. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified crude ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P08637 (UniProt, ExPASy) |
| UniProt Secondary AC | A2N6W9, Q53FJ0, Q53FL6, Q5EBR4, Q65ZM6, Q6PIJ0 |
| Molecular Weight | Calculated MW: 29.1 kDa |
| Buffer | Ascites containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |