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Farnesyl Diphosphate Synthase (FDPS) Antibody
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Catalogue No: abx004394
Price:
US$203.00
(Size: 20 µl)
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FDPS Antibody is a Rabbit Polyclonal antibody against FDPS. This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
Research Articles on Farnesyl Diphosphate Synthase (FDPS)
| Target | Farnesyl Diphosphate Synthase (FDPS) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/100 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 120-419 of human FPS/FDPS. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P14324 (UniProt, ExPASy) |
| UniProt Secondary AC | D3DV91, E9PCI9, Q96G29 |
| UniProt Entry Name | FPPS_HUMAN |
| Gene Symbol | FDPS |
| GeneID | 2224 |
| NCBI Accession | NP_001995.1 |
| KEGG | hsa:2224 |
| String | 9606.ENSP00000349078 |
| Molecular Weight | Calculated MW: 48 kDa Observed MW: 39 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |