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Feline Sarcoma Oncogene (FES) Antibody
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Catalogue No: abx015747
Price:
US$420.50
(Size: 100 µl)
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FES (feline sarcoma oncogene) and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases.FES and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain.They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains.FES was originally identified as an oncogene from avian and feline retroviruses.Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation.FES has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation.Mutations may activate the FES kinase and thereby contribute to cancer.However, recent data strongly suggests that the c-FES protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.
Research Articles on Feline Sarcoma Oncogene (FES)
| Target | Feline Sarcoma Oncogene (FES) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of FES expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P07332 (UniProt, ExPASy) |
| Gene Symbol | FES |
| GeneID | 2242 |
| OMIM | 190030 |
| HGNC | 3657 |
| Ensembl | ENSG00000182511 |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |