Feline Sarcoma Oncogene (FES) Antibody

FES (feline sarcoma oncogene) and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases.FES and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain.They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains.FES was originally identified as an oncogene from avian and feline retroviruses.Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation.FES has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation.Mutations may activate the FES kinase and thereby contribute to cancer.However, recent data strongly suggests that the c-FES protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.

Target	Feline Sarcoma Oncogene (FES)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA
Host	Mouse
Recommended dilutions	ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of FES expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P07332 (UniProt, ExPASy)
Gene Symbol	FES
GeneID	2242
OMIM	190030
HGNC	3657
Ensembl	ENSG00000182511
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Feline Sarcoma Oncogene (FES)

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