FYVE, RhoGEF And PH Domain-Containing Protein 4 (FGD4) Antibody

This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. [provided by RefSeq].

Target	FYVE, RhoGEF And PH Domain-Containing Protein 4 (FGD4)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 157-186 amino acids from the N-terminal region of human FGD4.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q96M96 (UniProt, ExPASy)
UniProt Secondary AC	Q6ULS2, Q8TCP6
UniProt Entry Name	FGD4_HUMAN
Gene Symbol	FGD4
KEGG	hsa:121512
String	9606.ENSP00000394487
Molecular Weight	Calculated MW: 86.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on FYVE, RhoGEF And PH Domain-Containing Protein 4 (FGD4)

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