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Fibroblast Growth Factor Receptor 3 (FGFR3) Antibody
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Catalogue No: abx033562
Price:
US$326.25
(Size: 80 µl)
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FGFR3 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.
Research Articles on Fibroblast Growth Factor Receptor 3 (FGFR3)
| Target | Fibroblast Growth Factor Receptor 3 (FGFR3) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 776-806 amino acids from the C-terminal region of human FGFR3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P22607 (UniProt, ExPASy) |
| UniProt Secondary AC | D3DVP9, D3DVQ0, Q14308, Q16294, Q16608, Q59FL9 |
| UniProt Entry Name | FGFR3_HUMAN |
| NCBI Accession | NP_000133.1 NP_001156685.1 NP_075254.1 |
| KEGG | hsa:2261 |
| String | 9606.ENSP00000339824 |
| Molecular Weight | Calculated MW: 87.7 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |