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Receptor-Type Tyrosine-Protein Kinase FLT3 (FLT3) Antibody
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Catalogue No: abx015860
Price:
US$420.50
(Size: 100 µl)
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This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Research Articles on Receptor-Type Tyrosine-Protein Kinase FLT3 (FLT3)
| Target | Receptor-Type Tyrosine-Protein Kinase FLT3 (FLT3) |
| Clonality | Monoclonal |
| Clone | M049 |
| Reactivity | Human |
| Tested Applications | ELISA, IHC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human FLT3 (AA: 930-991) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified from ascites by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P36888 (UniProt, ExPASy) |
| UniProt Secondary AC | A0AVG9, B7ZLT7, B7ZLT8, F5H0A0, Q13414 |
| UniProt Entry Name | FLT3_HUMAN |
| Gene Symbol | FLT3 |
| GeneID | 2322 |
| OMIM | 136351 |
| HGNC | 3765 |
| KEGG | hsa:2322 |
| Ensembl | ENSG00000122025 |
| String | 9606.ENSP00000241453 |
| Molecular Weight | 130 kDa |
| Buffer | PBS, containing 0.05% sodium azide. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |