+44 (0) 1223 755950
+1 832 327 7413
Dimethylaniline Monooxygenase [N-Oxide-Forming] 3 (FMO3) Antibody
REQUEST MORE INFO
Catalogue No: abx001558
Price:
US$217.50
(Size: 20 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
![Dimethylaniline Monooxygenase [N-Oxide-Forming] 3 (FMO3) Antibody](https://www.abbexa.com/image/cache/catalog/Antibody_Box-500x500.png)
FMO3 Antibody is a Rabbit Polyclonal antibody against FMO3. Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.
Research Articles on Dimethylaniline Monooxygenase [N-Oxide-Forming] 3 (FMO3)
| Target | Dimethylaniline Monooxygenase [N-Oxide-Forming] 3 (FMO3) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 263-532 of human FMO3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P31513 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R816, Q14854, Q8N5N5 |
| UniProt Entry Name | FMO3_HUMAN |
| Gene Symbol | FMO3 |
| GeneID | 2328 |
| NCBI Accession | NP_001002294.1 |
| KEGG | hsa:2328 |
| String | 9606.ENSP00000356729 |
| Molecular Weight | Calculated MW: 60 kDa Observed MW: 68 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |