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Farnesyltransferase Alpha (FNTA) Antibody
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Catalogue No: abx031598
Price:
US$326.25
(Size: 80 µl)
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FNTA, also known as CAAX farnesyltransferase (FTase), attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the so-called CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This type of posttranslational modification provides a mechanism for membrane localization of proteins that lack a transmembrane domain. This enzyme has the remarkable property of farnesylating peptides as short as four residues in length that conform to the CAAX consensus sequence. FNTA is also a specific cytoplasmic interactor of the transforming growth factor-beta and activin type I receptors. It is likely to be a key component of the signaling pathway which involves p21ras, an important substrate for farnesyltransferase.
Research Articles on Farnesyltransferase Alpha (FNTA)
| Target | Farnesyltransferase Alpha (FNTA) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 88-118 amino acids from the Central region of human FNTA. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P49354 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NJW0, Q53XJ9, Q9UDC1 |
| UniProt Entry Name | FNTA_HUMAN |
| KEGG | hsa:2339 |
| String | 9606.ENSP00000303423 |
| Molecular Weight | Calculated MW: 44.4 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat and Cow FNTA. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |