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FRAP1 (pT2446) Antibody
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Catalogue No: abx031982
Price:
US$326.25
(Size: 80 µl)
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FRAP1 belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. FRAP1 is a part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.
Research Articles on FRAP1 (pT2446)
| Target | FRAP1 (pT2446) |
| Clonality | Polyclonal |
| Target Modification | Thr2446 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | ELISA, DB |
| Host | Rabbit |
| Recommended dilutions | DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T2446 of human FRAP1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by protein A affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with peptides. The antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P42345 (UniProt, ExPASy) |
| UniProt Secondary AC | Q4LE76, Q5TER1, Q6LE87, Q96QG3, Q9Y4I3 |
| UniProt Entry Name | MTOR_HUMAN |
| NCBI Accession | NP_004949.1 |
| KEGG | hsa:2475 |
| String | 9606.ENSP00000354558 |
| Molecular Weight | Calculated MW: 289 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Rat MTOR. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |