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UDP-Glucose 4-Epimerase (GALE) Antibody
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Catalogue No: abx005057
Price:
US$203.00
(Size: 20 µl)
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GALE Antibody is a Rabbit Polyclonal antibody against GALE. This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.
Research Articles on UDP-Glucose 4-Epimerase (GALE)
| Target | UDP-Glucose 4-Epimerase (GALE) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 129-348 of human GALE. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q14376 (UniProt, ExPASy) |
| UniProt Secondary AC | A0A024RAH5, B3KQ39, Q38G75, Q86W41, Q9BVE3, Q9UJB4 |
| UniProt Entry Name | GALE_HUMAN |
| Gene Symbol | GALE |
| GeneID | 2582 |
| NCBI Accession | NP_001121093.1 |
| KEGG | hsa:2582 |
| String | 9606.ENSP00000483375 |
| Molecular Weight | Calculated MW: 38 kDa Observed MW: 38 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |