Guanidinoacetate N-Methyltransferase (GAMT) Antibody

GAMT Antibody is a Rabbit Polyclonal antibody against GAMT. The protein encoded by this gene is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affected individuals. Two transcript variants encoding different isoforms have been described for this gene. Pseudogenes of this gene are found on chromosomes 2 and 13.

Target	Guanidinoacetate N-Methyltransferase (GAMT)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/100 - 1/500, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-236 of human GAMT.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q14353 (UniProt, ExPASy)
UniProt Secondary AC	A8K0A0, Q53Y34, Q8WVJ1
UniProt Entry Name	GAMT_HUMAN
Gene Symbol	GAMT
GeneID	2593
NCBI Accession	NP_000147.1
KEGG	hsa:2593
String	9606.ENSP00000403536
Molecular Weight	Calculated MW: 26 kDa Observed MW: 29 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Guanidinoacetate N-Methyltransferase (GAMT)

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