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Gap Junction Alpha-1 Protein / CX43 (GJA1) Antibody
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Catalogue No: abx149629
Price:
US$406.00
(Size: 100 µg)
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Gap Junction Alpha-1 Protein / CX43 (GJA1) Antibody is a Rabbit Polyclonal antibody for the detection of Connexin-43. Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity).
Research Articles on Gap Junction Alpha-1 Protein / CX43 (GJA1)
| Target | Gap Junction Alpha-1 Protein / CX43 (GJA1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | gap junction protein, alpha 1, 43kDa |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P17302 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R5U9, Q6FHU1, Q9Y5I8 |
| UniProt Entry Name | CXA1_HUMAN |
| Gene Symbol | GJA1 |
| GeneID | 2697 |
| OMIM | 104100 |
| HGNC | 4274 |
| KEGG | hsa:2697 |
| Ensembl | ENSG00000152661 |
| String | 9606.ENSP00000282561 |
| Molecular Weight | Observed MW: 47 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |