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Grancalcin (GCA) Antibody
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Catalogue No: abx005357
Price:
US$203.00
(Size: 20 µl)
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GCA Antibody is a Rabbit Polyclonal antibody against GCA. This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.
Research Articles on Grancalcin (GCA)
| Target | Grancalcin (GCA) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-217 of human GCA. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P28676 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R5X3, Q53TB5, Q59EP3 |
| UniProt Entry Name | GRAN_HUMAN |
| Gene Symbol | GCA |
| GeneID | 25801 |
| NCBI Accession | NP_036330.1 |
| KEGG | hsa:25801 |
| String | 9606.ENSP00000394842 |
| Molecular Weight | Calculated MW: 24 kDa Observed MW: 24 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |