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Hexokinase-4 (GCK) Antibody
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Catalogue No: abx033753
Price:
US$290.00
(Size: 80 µl)
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Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of the gene for GCK results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in the gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), also called maturity onset diabetes of the young, type 2 (MODY2) ; mutations have also been associated with persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Research Articles on Hexokinase-4 (GCK)
| Target | Hexokinase-4 (GCK) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 403-433 amino acids from the C-terminal region of human GCK. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P35557 (UniProt, ExPASy) |
| UniProt Secondary AC | A4D2J2, A4D2J3, Q05810 |
| UniProt Entry Name | HXK4_HUMAN |
| NCBI Accession | NP_000153.1 NP_277042.1 NP_277043.1 |
| KEGG | hsa:2645 |
| String | 9606.ENSP00000223366 |
| Molecular Weight | Calculated MW: 52.2 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |