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Gamma-Glutamylcysteine Synthetase (GCLC) Antibody
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Catalogue No: abx030331
Price:
US$326.25
(Size: 80 µl)
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Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
Research Articles on Gamma-Glutamylcysteine Synthetase (GCLC)
| Target | Gamma-Glutamylcysteine Synthetase (GCLC) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 286-315 amino acids from the Central region of human GCLC. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P48506 (UniProt, ExPASy) |
| UniProt Secondary AC | Q14399 |
| UniProt Entry Name | GSH1_HUMAN |
| KEGG | hsa:2729 |
| String | 9606.ENSP00000229416 |
| Molecular Weight | Calculated MW: 72.8 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat GCLC. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |