Growth Differentiation Factor 5 (GDF5) Antibody

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.

Target	Growth Differentiation Factor 5 (GDF5)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 343-371 amino acids from the C-terminal region of human GDF5.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P43026 (UniProt, ExPASy)
UniProt Secondary AC	E1P5Q2, Q96SB1
UniProt Entry Name	GDF5_HUMAN
Gene Symbol	GDF5
KEGG	hsa:8200
String	9606.ENSP00000363492
Molecular Weight	Calculated MW: 55.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse GDF5.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Growth Differentiation Factor 5 (GDF5)

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