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Growth Differentiation Factor 5 (GDF5) Antibody
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Catalogue No: abx031516
Price:
US$326.25
(Size: 80 µl)
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GDF5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.
Research Articles on Growth Differentiation Factor 5 (GDF5)
| Target | Growth Differentiation Factor 5 (GDF5) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 13-41 amino acids from the N-terminal region of human GDF5. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P43026 (UniProt, ExPASy) |
| UniProt Secondary AC | E1P5Q2, Q96SB1 |
| UniProt Entry Name | GDF5_HUMAN |
| NCBI Accession | NP_000548.1 |
| KEGG | hsa:8200 |
| String | 9606.ENSP00000363492 |
| Molecular Weight | Calculated MW: 55.4 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |