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Glial Cell Line Derived Neurotrophic Factor (GDNF) Antibody
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Catalogue No: abx034059
Price:
US$290.00
(Size: 80 µl)
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GDNF is a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described.
Research Articles on Glial Cell Line Derived Neurotrophic Factor (GDNF)
| Target | Glial Cell Line Derived Neurotrophic Factor (GDNF) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 8-36 amino acids from the N-terminal region of human GDNF. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P39905 (UniProt, ExPASy) |
| UniProt Entry Name | GDNF_HUMAN |
| Gene Symbol | GDNF |
| KEGG | hsa:2668 |
| String | 9606.ENSP00000409007 |
| Molecular Weight | Calculated MW: 23.7 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |