Glial Cell Line Derived Neurotrophic Factor (GDNF) Antibody

GDNF is a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described.

Target	Glial Cell Line Derived Neurotrophic Factor (GDNF)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, IHC, FCM
Host	Rabbit
Recommended dilutions	IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 8-36 amino acids from the N-terminal region of human GDNF.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P39905 (UniProt, ExPASy)
UniProt Entry Name	GDNF_HUMAN
Gene Symbol	GDNF
KEGG	hsa:2668
String	9606.ENSP00000409007
Molecular Weight	Calculated MW: 23.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Glial Cell Line Derived Neurotrophic Factor (GDNF)

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