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Zinc Finger Protein Gfi-1 (GFI1) Antibody
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Catalogue No: abx012049
Price:
US$420.50
(Size: 100 µl)
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This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.Expression of GFl1 ranges from the hematopoietic and lymphoid system, to sensory epithelia, lung and parts of the CNS.
Research Articles on Zinc Finger Protein Gfi-1 (GFI1)
| Target | Zinc Finger Protein Gfi-1 (GFI1) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human GFI1 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q99684 (UniProt, ExPASy) |
| UniProt Secondary AC | Q8N564 |
| UniProt Entry Name | GFI1_HUMAN |
| Gene Symbol | GFI1 |
| GeneID | 2672 |
| OMIM | 600871 |
| HGNC | 4237 |
| KEGG | hsa:2672 |
| Ensembl | ENSG00000162676 |
| String | 9606.ENSP00000359357 |
| Molecular Weight | 45 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |