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GDNF Family Receptor Alpha 2 (GFRA2) Antibody
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Catalogue No: abx028008
Price:
US$290.00
(Size: 80 µl)
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Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI) linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.
Research Articles on GDNF Family Receptor Alpha 2 (GFRA2)
| Target | GDNF Family Receptor Alpha 2 (GFRA2) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 361-390 amino acids from the C-terminal region of human GFRA2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O00451 (UniProt, ExPASy) |
| UniProt Secondary AC | E9PD47, O15316, O15328, Q58J92, Q6GTR9, Q7Z5C2 |
| UniProt Entry Name | GFRA2_HUMAN |
| Gene Symbol | GFRA2 |
| KEGG | hsa:2675 |
| String | 9606.ENSP00000428518 |
| Molecular Weight | Calculated MW: 51.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse GFRA2. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |