Gastric Inhibitory Polypeptide Receptor (GIPR) Antibody

GIPR also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. This protein was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. The protein is involved in several other facets of the anabolic response.

Target	Gastric Inhibitory Polypeptide Receptor (GIPR)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 7-38 amino acids from the N-terminal region of human GIPR.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P48546 (UniProt, ExPASy)
UniProt Secondary AC	B7WP14, B7ZKQ0, Q14401, Q16400, Q52M04, Q9UPI1
UniProt Entry Name	GIPR_HUMAN
NCBI Accession	NP_000155.1
KEGG	hsa:2696
String	9606.ENSP00000467494
Molecular Weight	Calculated MW: 53.2 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Gastric Inhibitory Polypeptide Receptor (GIPR)

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