Glutaredoxin 1 (GLRX) Antibody

GLRX Antibody is a Rabbit Polyclonal antibody against GLRX. This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified.

Target	Glutaredoxin 1 (GLRX)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-106 of human GLRX.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P35754 (UniProt, ExPASy)
UniProt Secondary AC	B2R4L2, Q3KQS1, Q6ICT1
UniProt Entry Name	GLRX1_HUMAN
Gene Symbol	GLRX
GeneID	2745
NCBI Accession	NP_002055.1
KEGG	hsa:2745
String	9606.ENSP00000369314
Molecular Weight	Calculated MW: 12 kDa Observed MW: 12 kDa
Buffer	PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Glutaredoxin 1 (GLRX)

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