Glucose 6 Phosphate Isomerase (GPI) Antibody

Glucose 6 Phosphate Isomerase (GPI) Antibody is a Mouse Monoclonal antibody for the detection of GPI.

This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants.

Target	Glucose 6 Phosphate Isomerase (GPI)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Mouse
Recommended dilutions	WB: 1/2000 - 1/20000, IHC: 1/200 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Glucose-6-phosphate isomerase
Isotype	IgG1
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by Protein A and Protein G affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P06744 (UniProt, ExPASy)
UniProt Secondary AC	B4DG39, Q9BRD3, Q9BSK5, Q9UHE6
UniProt Entry Name	G6PI_HUMAN
Gene Symbol	GPI
GeneID	2821
OMIM	172400
HGNC	4458
KEGG	hsa:2821
Ensembl	ENSG00000105220
String	9606.ENSP00000405573
Molecular Weight	Observed MW: 55-64 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Glucose 6 Phosphate Isomerase (GPI)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue