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Glutamate Decarboxylase 1 (GAD1) Antibody
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Catalogue No: abx215526
Price:
US$406.00
(Size: 100 µg)
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Glutamate Decarboxylase 1 (GAD1) Antibody is a Rabbit Polyclonal antibody for the detection of GAD1. This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
Research Articles on Glutamate Decarboxylase 1 (GAD1)
| Target | Glutamate Decarboxylase 1 (GAD1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | glutamate decarboxylase 1 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | Q99259 (UniProt, ExPASy) |
| UniProt Secondary AC | Q49AK1, Q53TQ7, Q9BU91, Q9UHH4 |
| UniProt Entry Name | DCE1_HUMAN |
| Gene Symbol | GAD1 |
| GeneID | 2571 |
| OMIM | 603513 |
| NCBI Accession | NP_000808.2 |
| HGNC | 4092 |
| Ensembl | ENSG00000128683 |
| Molecular Weight | Observed MW: 67 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |