Glutathione Peroxidase 4 (GPX4) Antibody

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Catalogue No: abx216764
Price: US$406.00
(Size: 100 µg)

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Datasheet SDS
Glutathione Peroxidase 4 (GPX4) Antibody is a Rabbit Polyclonal antibody for the detection of GPX4.

The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.

Target Glutathione Peroxidase 4 (GPX4)
Clonality Polyclonal
Reactivity Human, Rat
Tested Applications ELISA, WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen glutathione peroxidase 4 (phospholipid hydroperoxidase)
Isotype IgG
Form Liquid
Purity ≥ 95% (SDS-PAGE)
Purification Purified by immunogen affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity 12 months.
UniProt Primary AC P36969 (UniProt, ExPASy)
UniProt Secondary AC O43381, Q6PJ59, Q9UPK2
UniProt Entry Name GPX4_HUMAN
Gene Symbol GPX4
GeneID 2879
OMIM 138322
HGNC 4556
KEGG hsa:2879
String 9606.ENSP00000346103
Molecular Weight Observed MW: 22 kDa
Buffer PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration 2 mg/ml
Availability Shipped within 5-12 working days.
Note This product is for research use only.
Research Articles on Glutathione Peroxidase 4 (GPX4)


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