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Geminin (GMNN) Antibody
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Catalogue No: abx004065
Price:
US$203.00
(Size: 20 µl)
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GMNN Antibody is a Rabbit Polyclonal antibody against GMNN. This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.
Research Articles on Geminin (GMNN)
| Target | Geminin (GMNN) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-209 of human GMNN. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O75496 (UniProt, ExPASy) |
| UniProt Secondary AC | B3KMM8, Q9H1Z1 |
| UniProt Entry Name | GEMI_HUMAN |
| Gene Symbol | GMNN |
| GeneID | 51053 |
| NCBI Accession | NP_056979.1 |
| KEGG | hsa:51053 |
| String | 9606.ENSP00000230056 |
| Molecular Weight | Calculated MW: 24 kDa Observed MW: 30 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |